Medel Manuel L. Zulueta, PhD
Organic Chemistry
Associate Professor
Academic Group Head, Organic Chemistry
Email: mlzulueta@up.edu.ph
Office Room and Phone No.: T131, Local 3664
Lab Room No.: R311-312
Research Laboratory: Carbohydrate Synthesis Laboratory
Education & Background
| Undergraduate | BS Chemistry, Polytechnic University of the Philippines, 1997 |
| Graduate | PhD Chemistry, UP Diliman, 2011 |
| Postdoctoral Training | Postdoctoral Fellow, Genomics Research Center, Academia Sinica, Taiwan, 6 years |
| Previous Employment & Appointments | Research Chemist, INA Research, Inc., Japan, 3 years URA1, Natural Sciences Research Institute, 1.5 years |
Teaching
| Chem 16: General Chemistry I |
| Chem 31: Elementary Organic Chemistry |
| Chem 33: Fundamentals of Organic Chemistry |
| Chem 34: Organic Reactions and Spectroscopy |
| Chem 230: Physical Organic Chemistry |
| Chem 237: Spectroscopic Methods in Organic Chemistry |
| Chem 242: Carbohydrates and Related Systems |
Research
Research Focus
Organic Synthesis and Carbohydrates Chemistry
Our laboratory is focused on carbohydrate synthesis. We are interested in carbohydrate structures, the development of strategies for their chemical preparation, and the evaluation of their structure–activity relationships.
Selected Publications
(1) C.-J. Yeh, M. M. L. Zulueta, Y.-K. Li, S.-C. Hung. Synthesis of hyaluronic acid oligosaccharides with a GlcNAc–GlcA repeating pattern and their binding affinity with CD44. Org. Biomol. Chem. 2020, 18, 5370–5387. https://doi.org/10.1039/d0ob01048k
(2) K. Sakamoto, T. Ozaki, Y.-C. Ko, C.-F. Tsai, Y. Gong, M. Morozumi, Y. Ishikawa, K. Uchimura, S. Nadanaka, H. Kitagawa, M. M. L. Zulueta, A. Bandaru, J.-i. Tamura, S.-C. Hung, K. Kadomatsu. Glycan sulfation patterns define autophagy flux at axon tip via PTPRσ-cortactin axis. Nat. Chem. Biol. 2019, 15, 699–709. https://doi.org/10.1038/s41589-019-0274-x
(3) M. M. L. Zulueta, D. Janreddy, S.-C. Hung. One-pot methods for the protection and assembly of sugars. Isr. J. Chem. 2015, 55, 347–359. https://doi.org/10.1002/ijch.201400171
(4) M. M. L. Zulueta, Y.-Q. Zhong, S.-C. Hung. Synthesis of L-hexoses and their related biomolecules. Chem. Commun. 2013, 49, 3275–3287. https://doi.org/10.1039/c3cc37733d
(5) M. M. L. Zulueta, S.-Y. Lin, Y.-T. Lin, C.-J. Huang, C.-C. Wang, C.-C. Ku, Z. Shi, C.-L. Chyan, D. Irene, L.-H. Lim, T.-I. Tsai, Y.-P. Hu, S. D. Arco, C.-H. Wong, S.-C. Hung. α-Glycosylation by D-glucosamine-derived donors: synthesis of heparosan and heparin analogues that interact with mycobacterial heparin-binding hemagglutinin. J. Am. Chem. Soc. 2012, 134, 8988–8995. https://doi.org/10.1021/ja302640p