Roger S. Tan, PhD
Biochemistry
Associate Professor
Email: rstan9@up.edu.ph
Office Room and Phone No.: T232, Local 3xxx
Lab Room: R209-210
Research Laboratory: RST Laboratory
Education & Background
| Undergraduate | BS Chemistry, Mindanao State University-Iligan Institute of Technology, 2007 |
| Graduate | Doctor of Life Science, Hokkaido University, 2015 MS Chemistry, Mindanao State University-Iligan Institute of Technology, 2011 |
| Previous Employment & Appointments | Assistant Professor, Faculty of Advanced Life Science and Graduate School of Life Science, Frontier Research Center for Advance Material and Life Science, Hokkaido University, Japan, 2021-2023 Associate Professor, Department of Chemistry, De La Salle University-Manila, 2018-2022 Professor, Department of Chemistry, Mindanao State University-Iligan Institute of Technology, 2018 Associate Professor, Department of Chemistry, De La Salle University-Manila, 2016-2017 R&D Researcher, Medicinal Chemistry Pharmaceuticals, Co., Ltd., Sapporo, Hokkaido, Japan, 2014-2015 |
Teaching
| Chem 16: General Chemistry I |
| Chem 40: Elementary Biochemistry |
| Chem 240: Advanced Biochemistry |
| Chem 349: Special Topics in Biochemistry (Glycobiochemistry and Glycan Technology) |
Research
Research Focus
Glycobiochemistry & Glycan Technology
Glycans mediate virtually all biological processes, such as cell-pathogen interaction, disease progression, and immune response modulation. Finding these mediator glycans and targeting them for therapeutic purposes has been very challenging due to the exquisitely complex nature of the biological system. We focus on finding these mediator glycans, through high-throughput Glycomics, that we can use as a glycan-based biomarker and as a therapeutic target.
Our goal is to design and develop therapeutic glycan mimics based on disease-specific glycan markers, develop these markers into a druggable target epitope, and use these markers as molecular targets in the delivery of therapeutic agents, using Nanoparticle-based Drug Delivery System (NDDS), with minimal perturbation and on the biological system. We have established a delivery platform that evades endolysosomal sequestration and successfully allows glycan-guided organelle targeting. Coupled with this platform, one of our goals is to fine-tune this technique and design a unique and comprehensive delivery system using a ‘bottom-up’ approach.
Selected Publications
(1) R. S. Tan. Glycosylated and non-glycosylated quantum dot-displayed peptides trafficked indiscriminately inside lung cancer cells but discriminately sorted in normal lung cells: An indispensable part in nanoparticle-based intracellular drug delivery. Asian J. Pharm. Sci. 2018, 13, 197-211. https://doi.org/10.1016/j.ajps.2017.12.002
(2) R. S. Tan. Modulation of Cancer Cell Proliferation by unusually produced β(1-6) linked Mannan-oligosaccharides and β(1-6) linked Galacto-oligosaccharides using β–galactosidase from Aspergillus oryzae. Int. J. Advances Appl. Sci., 2018, 5(4): 30-41. https://doi.org/10.21833/ijaas.2018.04.005
(3) R. S. Tan, H. Hinou, S.-I. Nishimura. Novel β-galactosynthase–β-mannosynthase dual activity of β-galactosidase from Aspergillus oryzae uncovered using monomer sugar substrates. RSC Adv. 2016, 6, 50833-50836. https://doi.org/10.1039/C6RA08060J
(4) R. S. Tan, K. Naruchi, H. Hinou, M. Amano, S-I. Nishimura. Rapid endolysosomal escape and controlled intracellular trafficking of cell surface mimetic quantum dots-anchored peptides and glycopeptides. ACS Chem. Biol. 2015, 10, 2073-2086 (Cover: ACS Chemical Biology in September 2015). https://doi.org/10.1021/acschembio.5b00434
Awards & Extension Work
| 2019-Present: Review Board Member-Reviewer, Bio-Protocol Journal, Bio-Protocol LLC, Sunnyvale CA, USA |